Multimodal Integration for Heart Transplant Rejection
Chunqing (Tony) Liang
PhD student in Bioinformatics
Supervisor: Dr. Amrit Singh
Oct 6, 2025
Land acknowledgement
I would like to acknowledge that I work on the traditional, ancestral, and unceded territory of the Coast Salish Peoples, including the territories of the xwməθkwəy̓əm (Musqueam), Skwxwú7mesh (Squamish), Stó:lō and Səl̓ílwətaʔ/Selilwitulh (Tsleil- Waututh) Nations.
Traditional: Traditionally used and/or occupied by Musqueam people
Ancestral: Recognizes land that is handed down from generation to generation
Unceded: Refers to land that was not turned over to the Crown (government) by a treaty or other agreement
Background Heart Transplant
TODO
Background Heart Rejection
TODO
Background types of rejection …
Background ACR vs Quilty
TODO
Background Types of data
TODO
Background In-house data
Cite collaborators
Or have their names and pic in here
Background what method to apply
Need to know which method is most suitable to apply on this
Which there really isnt any after the pipeline run
Objective
Improve diagnosis using multimodal data
Can we tell long term outcome of rejection?
MESSI pipeline
MESSI pipeline Input Processing
Currently handles both R and Python –> could extend to more
Data flows in there …
Important model selection prior to evaluation
MESSI pipeline Method Evaluation
Each method is an isolated workflow (dash box)
Each method internally runs evaluation in parallel
Each result is saved separately …
MESSI pipeline Output Collection
Computational Resources Usage
Performance on real-world datasets
Biological Interpretation on biomarkers identified
