Multimodal Integration for Heart Transplant Rejection


Chunqing (Tony) Liang

PhD student in Bioinformatics

Supervisor: Dr. Amrit Singh

Oct 6, 2025

Land acknowledgement

I would like to acknowledge that I work on the traditional, ancestral, and unceded territory of the Coast Salish Peoples, including the territories of the xwməθkwəy̓əm (Musqueam), Skwxwú7mesh (Squamish), Stó:lō and Səl̓ílwətaʔ/Selilwitulh (Tsleil- Waututh) Nations.

Traditional: Traditionally used and/or occupied by Musqueam people

Ancestral: Recognizes land that is handed down from generation to generation

Unceded: Refers to land that was not turned over to the Crown (government) by a treaty or other agreement

Background Heart Transplant

  • TODO

Background Heart Rejection

  • TODO

Background types of rejection …

Background ACR vs Quilty

  • TODO

Background Types of data

  • TODO

Background In-house data

  • Cite collaborators
  • Or have their names and pic in here

Background what method to apply

  • Need to know which method is most suitable to apply on this
  • Which there really isnt any after the pipeline run

Objective

  • Improve diagnosis using multimodal data

  • Can we tell long term outcome of rejection?

MESSI pipeline

MESSI pipeline Input Processing

  • Currently handles both R and Python –> could extend to more
  • Data flows in there …
  • Important model selection prior to evaluation

MESSI pipeline Method Evaluation

  • Each method is an isolated workflow (dash box)
  • Each method internally runs evaluation in parallel
  • Each result is saved separately …

MESSI pipeline Output Collection

Computational Resources Usage

Performance on real-world datasets

Biological Interpretation on biomarkers identified

MESSI future direction

  • TODO

Current work on GeoMX

  • TODO

Background of GeoMX

  • TODO

GeoMx results 1

GeoMx results 2

GeoMx results 3

GeoMx results 4

  • TODO

Next steps

  • TODO

Conclusion

  • TODO

Acknowledgments

Reference